The UNC5 family of proteins are involved in netrin-mediated signaling events in blood vessel patterning, axonal migrations, and apoptosis. Members of this family generally contain three domains, ZU5, UPA, and death domain (DD), which are important to UNC5 protein function. UNC5CL (UNC5C-like protein), also known as protein UNC5 homolog C-like or zud (ZU5 and death domain-containing protein), is a 518 amino acid single-pass type III membrane protein that belongs to the UNC5 family and contains one death domain and a ZU5 domain. Localizing to cytoplasm as well as membrane, UNC5CL impairs NF-kappa-B binding to its targets thus inhibiting NF-kappa-B-dependent transcription. UNC5CL exists as four alternatively spliced isoforms.